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KMID : 0895820090190040001
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Journal of Oriental Rehabilitation Medicine
2009 Volume.19 No. 4 p.1 ~ p.18
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A Study on the Effect of Changchuldointanggami-bang in Rheumatoid Arthritis
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Park Eun-Sook
Yoon Il-Ji
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Abstract
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Objectives: This study was carried out to understand the immune responses of the Changchuldointanggami-bang(afterreferredtoCDIT) on antioxidants,THP-1cell and rheumatoid arthritis in Collagen-induced Arthritis(CIA) mice.
Methods: The antioxidative effect of CDIT on DPPH free radical and SOD like activity was measured.CDITwas administered to THP-1 cell,cytokine and mRNA associated with inflammation were measured. CDITwas orally administered to mice with arthritis by collagenⅡ and then cytokine, PBMC in the serum were measured.
Results: 1.The scavenging activity of CDIT on DPPH free radical was dose-dependent. 2.The effect of CDIT on SOD-like activity was dose-dependent. 3.The production of IL-1β, IL-6, TNF-α was decreased significantlyin THP-1 cell.
4.The expression of IL-1β mRNA, IL-6mRNA, TNF-α mRNA were decreased significantly in THP-1 cell. 5.IL-1β, IL-6, TNF-α were decreased significantly in the serum of CIA mice. 6.CD3+, CD4+, CD8+ were increased significantly, but CD3+/CD69+, CD3+/CD49b+, B220+/CD23+ were decreased significantly in PBMC of CIA mice.
Conclusions:: Taking all these observations into account, CDIT is considered to be effective in rheumatoid arthritis. Therefore we have to survey continuously in looking for the effective substance and mechanism in the future.
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KEYWORD
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Changchuldoin-tanggamibang(CDIT), Antioxidativeeffect, CollageninducedArthritis(CIA), Cytokine
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